TES is an NGS-based, time and cost-effective approach to investigate regions of interest in the genome. GeneWerk has streamlined this approach for on-/off-target analysis for gene editing safety assessment.
GeneWerk’s TES approach for on-/off-target analysis is based on the selective capture of a target sequence using biotinylated RNA ‘baits’ homologous to the genomic sequence of interest.
Apart from donor and vector sequence-specific RNA baits, we also include pre-designed RNA baits targeting in-silico predicted genomic areas.
This helps us to capture and analyze not only thousands of predicted off-target events but also indels, translocations and non-predicted off-target alterations close to these predicted sites.
Read our latest press releases and announcements below.
GeneWerk will expand capabilities to meet rapidly growing demand for cell and gene therapy...