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A largely random AAV integration profile after…

Abstract The clinical application of adeno-associated virus vectors (AAVs) is limited because of concerns...
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AAVvector-mediated in vivo reprogramming into pluripotency

Abstract In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds...
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An unbiased genome-wide analysis of zinc-finger nuclease…

Abstract Zinc-finger nucleases (ZFNs) allow gene editing in live cells by inducing a targeted...
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Analyzing the Number of Common Integration Sites…

Abstract Vectors based on γ-retroviruses or lentiviruses have been shown to stably express therapeutical...
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Bioinformatic clonality analysis of next-generation sequencing-derived viral…

Abstract Clonality analysis of viral vector-transduced cell populations represents a convincing approach to dissect...
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Clonality analysis after retroviral-mediated gene transfer to…

Abstract A clinical trial of retroviral-mediated transfer of the adenosine deaminase (ADA) gene into...
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Comprehensive genomic access to vector integration in…

Abstract Retroviral vectors have induced subtle clonal skewing in many gene therapy patients and...
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Correction of X-linked chronic granulomatous disease by…

Abstract Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid...
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GeneWerk is led by renowned experts
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Dr. Irene Gil-Fariña

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Dr. Annette Deichmann

Managing Director
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Dr. Manfred Schmidt

CEO
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